Autoimmunity is triggered by cPR-3 (105-201), a protein complementary to human autoantigen proteinase-3

Article Abstract:

Immunization of mice with the middle region of cPR-3 resulted in production of antibodies not only to cPR-3 , but also to the immunogen's sense peptide counterpart, proteinase-3 (PR-3). Both human and mouse antibodies to PR-3 and cPR-3 bound to each other indicating idiotypic relatioships.

Animal experimentation, Immunization

---

Autoimmunity: busting the atherosclerotic plaque

Article Abstract:

Autoimmunity is suspected to be a major contributor to the formation of atherosclerotic plaques. Autoimmunity might contribute to atherosclerosis with the realization that the development of the atherosclerotic plague involves both natural (innate) and adaptive immunity.

Influence, Atherosclerotic plaque

---

The idiotypic network in autoimmunity: antibodies that bind antibodies that bind antibodies

Article Abstract:

A new theory about the development of autoimmunity has emerged from a surprising and miscellaneous set of observations. The elements include antibodies that recognize antibodies and a peculiar structural relationship between a sense and antisense-ecoded protein.

Viral antibodies, Antibodies

Similar abstracts:

• Abstracts: Disappearance of humoral thyroid autoimmunity after complete removal of thyroid antigens. Methimazole and serum thyroid hormone concentrations in hyperthyroid patients: effects of single and multiple daily doses
• Abstracts: Turning neurogenesis up a notch. Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease
• Abstracts: Pulmonary alveolar proteinosis - is host defense awry? GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis
• Abstracts: Protein microarrays for multiplex analysis of signal transduction pathways. CD4+CD25+ regulatory T cells preserve graft-versus-tumor captivity while inhibiting graft-versus-host disease after bone marrow plantation
• Abstracts: Asian epidemic, abstinence top AIDS meeting agenda. Malik Peiris. Natural-born killers

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.