Turning neurogenesis up a notch

Article Abstract:

Scientists report that signaling through Notch, a single-pass transmembrane receptor activated by ligands on adjacent walls, may hold a key to the regulation of neurogenesis, including neurogenesis that occur after stroke. Experiments in a rat model indicated that activation of Notch could also stimulate neurogenesis and healing after stroke.

Health aspects, Care and treatment, Stroke (Disease), Stroke

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Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease

Article Abstract:

Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end-stage renal disease. An orthologous mouse model is presented that shows response to OPC31260 treatment with presentation of renal enlargement, marked inhibition of cystogenesis and protection of renal function.

Causes of, Risk factors, Polycystic kidney disease, Kidney diseases

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Inhibition of renal cystic disease development and progression by a vasopressin V2receptor antagonist

Article Abstract:

Research shows that administration of the vasopressin V2 receptor antagonist, OPC31260, lowers renal cyclic AMP, arrests renal cystic disease development and either inhibits progression or regresses established disease.

Influence, Diseases, Cyclic adenylic acid, Cyclic adenosine monophosphate, Vasopressin, Vasopressins, Kidney, Cystic, Cystic kidney

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