IKK mediates ischemia-induced neuronal death

Article Abstract:

A study to investigate the I(kappa)B kinase complex, IKK is presented by generating mice that contained a targeted deletion of lkbkb (which encodes IKK2) in the mouse neurons and mice that express a dominant inhibitor of IIK in neurons. The results revealed a key function of IKK in the ischemic brain damage and suggested a potential role for IIK inhibitors in stroke therapy.

Protein kinases, Ischemia

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The eukaryotic transcriptional machinery: complexities and mechanisms unforseen

Article Abstract:

This article describes cell-specific protein synthesis during pancreatic development and regulation of the RNA synthesis. Research discusses nuclear RNA polymerases with respect to its multiplicity, structure and functions. Also, reconstitution of accurate transcription, regulation of transcription and transcriptional coactivators are also described.

Analysis, Physiological aspects, Protein synthesis, RNA polymerases, Protein biosynthesis, Structure-activity relationships (Biochemistry), RNA synthesis

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A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

Article Abstract:

A study to address whether the transcriptional characteristics of hepatocellular carcinoma (HCC) could provide insight into the cellular origin of the tumor was conducted. The analyses of gene networks showed that activation of AP-1 transcriptional factors in the newly identified HCC subtype might have the key roles in tumor development.

Genetic aspects, Hepatoma, Hepatocellular carcinoma

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