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Azithromycin for the secondary prevention of coronary heart disease events: a randomized controlled trial

Article Abstract:

The antibiotic azithromycin did not reduce the risk of a second heart attack or premature death in 7,747 heart attack patients. All of the patients also tested positive for Chlamydia pneumoniae, a bacteria that has been linked to coronary artery disease. For this reason, doctors believed an antibiotic might benefit these patients. In this particular study, it did not.

Author: O'Connor, Christopher M., Pfeffer, Marc A., Dunne, Michael W., Muhlestein, Joseph B., Yao, Louis, Gupta, Sandeep, Benner, Rebecca J., Fisher, Marian R., Cook, Thomas D.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
Evaluation, Prevention, Drug therapy, Heart attack, Chlamydia infections, Azithromycin

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Effects of tezosentan on symptoms and clinical outcomes in patients with acute heart failure

Article Abstract:

A study is conducted to find if endothelin receptor antagonist tezosentan improves outcomes in patients with acute heart failure. The results suggest that tezosentan did not improve symptoms or clinical outcomes in patients with acute heart failure.

Author: O'Connor, Christopher M., Bourge, Robert C., Krum, Henry, Kobrin, Isaac, McMurray, John J.V., Parker, John D., Teerlink, John R., Cotter, Gadi, Cleland, John G.F., Jondeau, Guillaume, Metra, Marco, Torre-Amione, Guillermo, van Veldhuisen, Dirk J., Lewsey, Jim, Frey, Aline, Rainisio, Maurizio
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
United States, Endothelin, Clinical report, Tezosentan

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Palliative care for patients with heart failure

Article Abstract:

Heart failure accounts for more hospitalizations among Medicare beneficiaries than any other condition. With the combination of optimal medical management with palliative care, physicians can best care for heart failure patients and their families.

Author: Pantilat, Steven Z., Steimle, Anthony E.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
Care and treatment, Palliative treatment, Palliative care, Patient care

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Subjects list: Research, Heart failure
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