Back to the future: the 'old-fashioned' way to new medications for neurodegeneration

Article Abstract:

Progress towards effective treatments of neurodegenerative diseases is remarkably slow. There are number of obstacles towards discovery of effective drug for neurodegeneration but a consideration of these problems would make it possible to identify lessons for the future.

Care and treatment, Evaluation, Nervous system, Neurodegenerative diseases

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APCs size up antigens

Article Abstract:

Intracellular antigens pose a challenge to the immune response and to vaccine development. Three studies examine the process of antigens entering antigen-presenting cells, implicating whole proteins instead of small peptides as key intermediaries.

United States, Immune response, Antigen presenting cells

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Immunotherapy of established tumors using bone marrow transplantation with antigen gene-modified hematopoietic stem cells

Article Abstract:

The strategies to induce T-cell responses through presentation of tumor antigens by dendritic cells (DCs) a major focus of cancer immunotherapy is illustrated. The results are used to discover more efficient treatments for the diseases.

Bone marrow transplantation, Hematopoietic stem cells, Immunotherapy

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