Cardiotoxicity of the cancer therapeutic agent imatinib mesylate

Article Abstract:

A report on individuals who developed severe congestive heart failure while on imatinib mesylate (Gleevec), which is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia is presented. The data results derived from studies in cultured cardiomyocytes, mice and humans, suggest that imatinib is cardiotoxic and, in humans, could lead to severe left ventricular dysfunction and heart failure.

Health aspects, Causes of, Complications and side effects, Drug therapy, Genetic aspects, Heart failure, Chronic myeloid leukemia, Imatinib mesylate

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Antibacterial resistance worldwide: Causes, challenges and responses

Article Abstract:

The optimism of the early period of antimicrobial discovery is tempered by the emergence of bacterial strains with resistance to the therapeutics. It is showed that drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs.

Research and Development in the Physical, Engineering, and Life Sciences, Science & research, Research and Testing Services, Medical Research, Epilepsy & Muscle Disease R&D, Administration of Public Health Programs, Health Research Programs, Research, Antimicrobial additives, Medicine, Experimental

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