Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

Article Abstract:

The treatment of hyperlipidemic hamsters with berberine (BBR) reduced serum cholesterol by 40% and LDL-cholesterol by 42%, with a 3.5-fold increase in hepatic lipoprotein receptor (LDLR) mRNA and a 2.6-fold increase in hepatic LDLR protein is studied. These findings show BBR as a new hypolipidemic drug with a mechanism of action different from that of stain drugs.

Science & research, Care and treatment, Cholesterol, Hyperlipidemia, Berberine

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Experts predict bleak post-genomic era for drug R&D

Article Abstract:

Issues related to the economic implications of the human genome project for the pharmaceutical industry are examined, focusing on the sharp rise in research and development costs that would take place if companies were to target new medicines associated with opportunities created by the human genome project.

Economic aspects, Forecasts and trends, Human Genome Project, Pharmaceutical research

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CYP3A genetics in drug metabolism

Article Abstract:

Issues related to the research on the CYP3A enzyme, which allows most drugs to be metabolized are examined, focusing on how the human genome project may affect future research on the genetic factors thart regulate enzyme expression.

Drugs, Genetic aspects, Enzymes, Pharmaceutical microbiology

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