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Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity

Article Abstract:

The B7-H1 is a cell-surface glycoprotein and is upregulated in tumor-associated myeloid dendritic cells, which results in conferring suppressive functions to the tumor-infiltraing myeloid dendritic cells in ovarian cancer patients. Blockade of B7-H1 increases myeloid dendritic cell-mediated T-cell activation leading to inhibition of autologous human ovarian carcinoma growth.

Author: Chen, Lieping, Curiel, David T., Zou, Weiping, Wei, Shuang, Krzysiek, Roman, Gordon, Alan, Emilie, Dominique, Curiel, Tyler J., Dong, Haidong, Alvarez, Xavier, Cheng, Pui, Mottram, Peter, Knutson, Keith L., Daniel, Ben, Zimmermann, Maria Carla, David, Odile, Burow, Matthew, Dhurandhar, Nina, Myers, Leann, Berggren, Ruth, Hemminki, Akseli, Alvarez, Ronald D.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Glycoproteins, Growth, Ovarian cancer, Immunity, Immunity (Physiology), Cellular control mechanisms, Cell regulation, Company growth

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Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells

Article Abstract:

Research has been conducted on the function and trafficking of dendritic cells in tumors. Results indicate that tumors may weaken immunity by attracting plasmacytoid dendritic cell precursors and protecting them from microenvironment and by altering myeloid dendritic cell distribution.

Author: Curiel, David T., Zou, Weiping, Machelon, Veronique, Coulomb-L'Hermin, Aurore, Borvak, Jozef, Nome, Francoise, Isaeva, Tatyana, Wei, Shuang, Krzysiek, Roman, Durand-Gasselin, Ingrid, Gordon, Alan, Pustilnik, Terri, Galanaud, Pierre, Capron, Frederique, Emilie, Dominique, Curiel, Tyler J.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Causes of, Genetic aspects, Tumors, Antigen presenting cells, Immune system

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Acute activation of CD8+ T lymphocytes in interleukin-2-treated HIV-infected patients

Article Abstract:

Interleukin-2 appears to activate CD8+ T lymphocytes, which are also called killer T cells. These cells are responsible for killing microorganisms in the body, including HIV. Interleukin-2 is a naturally occurring substance in the body that is often used therapeutically.

Author: Levy, Yves, Zou, Weiping, Durand-Gasselin, Ingrid, Galanaud, Pierre, Emilie, Dominique, Foussat, Arnaud, Capitant, Catherine, Bouchet, Laurence
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 1999
Interleukin-2, CD8 lymphocytes

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Subjects list: United States, France, Physiological aspects
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