Hsp 70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

Article Abstract:

Influence of mammalian heat-shock proteins (HSPs) on the immune response to antigens is determined in vivo. The effects of Hsp70 on induction of autoimmunity using the lymphocytic choriomeningitis virus glycoprotein (LCMV-GP) model of autoimmune diabetes are examined.

Antigen presenting cells

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Human lupus T cells resist inactivation and escape death by upregulating COX-2

Article Abstract:

Studies with COX-2 inhibitors and COX-2-deficient mice confirmed that COX-2/FLIP (FLICE inhibitory protein) antiapoptosis program is used by Human lupus T cells. Mechanisms of COX-2 inhibitor induced apoptosis are presented.

United States, Apoptosis

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Positive selection for autoimmunity

Article Abstract:

The most well-known mechanism for tolerating self antigens is negative selection of T cells in the thymus. However, a new model of autoimmune disease suggests procainamide catalysis offers other possibilities.

Models, Autoimmune diseases, Thymus, Thymus gland

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