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Brief report: Severe infectious mononucleosis-like syndrome and primary human herpesvirus 6 infection in an adult

Article Abstract:

Human herpesvirus 6 (HHV-6) may cause a severe infectious mononucleosis-like syndrome in adults. HHV-6 is a virus that was first identified in AIDS patients and patients with different types of lymphoproliferative disorders. A 43-year-old man was admitted to a hospital with a fever of seven days duration and a rash over his entire body. He also had other symptoms characteristic of mononucleosis. These included swollen lymph nodes, mild enlargement of the spleen and sore throat. A blood test revealed antibodies against HHV-6. HHV-6 DNA was also detected in a blood sample, peripheral blood mononuclear cells, CD4+ T-cells and a sample of skin tissue. An HHV-6 infection was determined to be the cause of the patient's illness.

Author: Akashi, Koichi, Niho, Yoshiyuki, Kikuchi, Masahiro, Eizuru, Yoshito, Sumiyoshi, Yoshiaki, Minematsu, Toshio, Hara, Sachiko, Harada, Mine, Minamishima, Yoichi
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1993
Development and progression, Mononucleosis, Infectious mononucleosis

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A relapsing inflammatory syndrome and active human herpesvirus 8 infection

Article Abstract:

A description about an immunocompetent 61-year old woman who was negative for human immunodeficiency virus and who had recurrent human herpesvirus 8 (HHV-8) infection associated with a relapsing systematic inflammatory syndrome characterized by fever, lymphadenopathy, splenomegaly, edema and rash is presented. The HHV-8 infection, also known as Kaposi's sarcoma (KS)- associated herpesvirus developed 10 months after the initial clinical presentation.

Author: Malnati, Mauro S., Lusso, Paolo, Sabbadini, Maria Grazia, Ferrarini, Marina, Danga, Lorenzo, Broccolo, Francesco, Paties, Carlo T., Sarmati, Loredana, Praderio, Luisa
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
New England States, Case studies, Diseases, New England, Recurrence (Disease), Herpes

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Expression of human herpesvirus 8 in primary pulmonary hypertension

Article Abstract:

Human herpesvirus-8 (HHV-8) may be responsible for causing pulmonary hypertension in some people, according to a study of 30 patients. Lung tissue biopsy samples from 10 of the 16 patients with primary pulmonary hypertension tested positive for HHV-8. Pathological analysis of the samples revealed similarities with Kaposi's sarcoma tumors on the skin of HIV patients. Kaposi's sarcoma is also linked to HHV-8 infection.

Author: Voelkel, Norbert F., Cool, Carlyne D., Rai, Pradeep R., Yeager, Michael E., Hernandez-Saavedra, Daniel, Serls, Amanda E., Bull, Todd M., Geraci, Mark W., Brown, Kevin K., Routes, John M., Tuder, Rubin M.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
Pulmonary hypertension

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Subjects list: Causes of, Herpesvirus diseases, Herpesvirus infections, Health aspects, Human herpesvirus 8
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