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Building towards a consensus for the use of tumour necrosis factor blocking agents

Article Abstract:

More research is needed to determine whether drugs that block the activity of tumor necrosis factor (TNF) are effective and safe for patients with rheumatoid arthritis. A special supplement to the December 1999 issue of Annals of Rheumatic Diseases reports results from a conference on TNF blockers.

Author: Smolen, J.S., Breedveld, F.C., Kalden, J.R., Furst, D.E.
Publisher: British Medical Association
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1999

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PEGylated recombinant human soluble tumour necrosis factor receptor type I (r-Hu-sTNF-RI): novel high affinity TNF receptor designed for chronic inflammatory diseases

Article Abstract:

Attaching polyethylene glycol (PEG) to the receptor for tumor necrosis factor (TNF) should result in a drug that will last a fairly long time in the body. TNF has been implicated in the development of some inflammatory diseases, and the drug would block its activity.

Author: Edwards, Carl K., III
Publisher: British Medical Association
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1999
Research, Polyethylene glycol

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Etanercept: therapeutic use in patients with rheumatoid arthritis

Article Abstract:

The drug etanercept appears to be effective in treating rheumatoid arthritis. This drug is a synthetic form of the receptor for tumor necrosis factor (TNF), which has been implicated in the development of rheumatoid arthritis. The drug blocks the activity of TNF.

Author: Garrison, Leslie, McDonnell, Neil D.
Publisher: British Medical Association
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1999

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Subjects list: Health aspects, Drug therapy, Rheumatoid arthritis, Tumor necrosis factor, Cell receptors
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