C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: correlations with birth weight

Article Abstract:

Insulin-like growth factor (IGF) I level influences birth weight. Insulin-like growth factor II and insulin are also related to fetal growth. Blood samples taken during the third trimester of pregnancy from the umbilical cords of 538 infants were analyzed and compared with the infants' birth weights. Concentrations of IGF-I increased in average-birth-weight (AGA) infants until the 39th week of pregnancy. After that, there was a 21% decrease until 41 weeks. Small-for-gestational-age (SGA) infants had levels of IGF-I that were 40% lower on average than AGA or large for gestational age (LGA) infants. IGF-II was 10% higher in LGA infants than in SGA infants and 8% higher than in AGA infants. However, SGA and AGA infants had similar levels of IGF-II. Higher levels of insulin-like growth factor binding protein-1 were found in newborns with evidence of growth retardation.

Birth weight

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Insulin-like growth factor binding protein-1 at the maternal-fetal interface and insulin-like growth factor-I, insulin-like growth factor-II, and insulin-like growth factor binding protein-1 in the circulation of women with severe preeclampsia

Article Abstract:

Insulin-like growth factor binding protein-1 (IGFBP-1) may play a role in the shallow placental implantation seen in severe preeclampsia. Preeclampsia is a serious complication of pregnancy involving hypertension and protein in the urine. Researchers examined levels of IGFBP-1 at the maternal-fetal interface in eight pregnancies characterized by severe preeclampsia and in six normal pregnancies between 21 and 34 weeks of pregnancy. IGFBP-1 levels were higher at the interface of preeclamptic pregnancies and were linked with high diastolic blood pressure. Low insulin-like growth factor-I levels were found in preeclamptic pregnancies, which may cause poor fetal growth.

Measurement, Preeclampsia

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Regulation of insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses

Article Abstract:

The authors have evaluated the factors regulating insulin-like growth factor binding protein-1 concentrations in preterm fetuses. They report that insulin-like growth factor-I is related to gestational age and the in utero growth potential, and insulin-like growth factor binding protein-1 is related only to the in utero growth potentials.

United States, Belgium, Health aspects, Causes of, Complications and side effects, Fetus, Genetic aspects, Growth factors, Genetic regulation, Premature labor, Insulin, Binding proteins, Premature labour

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