Effect of Genetic Differences in Omeprazole Metabolism on Cure Rates for Helicobacter pylori Infection and Peptic Ulcer

Article Abstract:

Many patients with Helicobacter pylori infection may have different cure rates depending on genetic differences in the enzyme S-mephenytoin 4'-hydroxylase (CYP2C19). This liver enzyme metabolizes the drug omeprazole, which is used to treat Helicobacter pylori infection. Helicobacter pylori infection has been linked to peptic ulcer. In a study of 62 Japanese patients with Helicobacter pylori infection, those who metabolized omeprazole quickly had a 28% cure rate, those who metabolized the drug more slowly had a 60% cure rate and those who metabolized the drug the slowest had a 100% cure rate. Their ulcers healed at similar rates.

Health aspects, Drug therapy, Helicobacter infections, Drug metabolism

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Combination treatment for peptic ulcers at high risk for recurrent bleeding

Article Abstract:

Endoscopic treatment combined with the proton pump inhibitor omeprazole is more effective for preventing recurrent peptic ulcer bleeding in patients with a high risk of recurrent bleeding than omeprazole alone, according to a study of 156 patients. Risk factors for recurrent bleeding include visible blood vessels during endoscopy or a blood clot on a blood vessel. Endoscopic treatment involves using a heat probe to seal a bleeding blood vessel.

Prevention, Gastrointestinal bleeding, Gastrointestinal hemorrhage

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Treatment of patients at high risk for recurrent bleeding from a peptic ulcer

Article Abstract:

Patients who have a peptic ulcer that has bled in the past should be treated with thermal coagulation and an intravenous proton pump inhibitor such as omeprazole if endoscopy detects visible blood vessels or a blood clot on a blood vessel. Thermal coagulation can be delivered via endoscopy. The combined treatment may be more effective than proton pump inhibitors alone.

Editorial

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