CA 125 kinetics: a cost-effective clinical tool to evaluate clinical trial outcomes in the 1990s

Article Abstract:

A significant reduction in the level of cancer indicator CA 125 after chemotherapy may indicate a good chance of survival after ovarian cancer. Researchers computed the slope of the curve of CA 125 reduction after chemotherapy for ovarian cancer for 126 women. The slope of CA 125 reduction was found to be a more important indicator of survival than age, stage or grade of cancer, amount of chemotherapy, or remaining cancer. The ideal slope of CA 125 reduction was computed from the 11 women whose cancers were eliminated for an average of 62 months. Chemotherapy may be initiated immediately after surgery to remove tumors to maximize the chance of survival. The slope of CA 125 reduction after chemotherapy may be useful in making decisions about additional cancer treatments.

Measurement, Prognosis, Ovarian cancer, Tumor antigens

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Developmental outcomes of children with myelomeningocele: prenatal predictors

Article Abstract:

The position and severity of the spinal lesion in children with spinal cord abnormalities appears to be associated with developmental and brain function. Fetal ultrasound images of 23 infants born with spinal cord abnormalities were compared with developmental and thinking skills tests performed on these children between one and three years of age. Test scores were higher for children with less severe lesions or with lesions located lower on the spine. Twelve of these children had reached school age. Six children were in mainstream classrooms fulltime. However, more children with severe lesions were in special education classes or had repeated a grade level.

Psychological aspects, Cognition in children, Cognitive development, Myelomeningocele, Meningomyelocele

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Oral terbutaline after parenteral tocolysis: a randomized, double-blind, placebo-controlled trial

Article Abstract:

Oral terbutaline treatment does not appear to prolong pregnancy in women experiencing preterm labor. Researchers randomly assigned 200 women between 24 and 35 weeks gestation whose preterm labor had been stopped with intravenous medication to either oral terbutaline or a placebo. No differences were found in the incidence of birth within one week, average length of time before labor, average gestational age at birth, or the incidence of subsequent episodes of preterm labor. However, oral terbutaline treatment may be of benefit in women prior to 32 weeks gestation.

Prevention, Premature labor, Terbutaline

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