Development and characterization of an interleukin-2-transduced human ovarian carcinoma tumor vaccine not expressing major histocompatibility complex molecules

Article Abstract:

A cancer vaccine derived from interleukin-2 secretions from tumors may potentially be used to treat women with advanced ovarian cancer. Researchers genetically engineered a cancer vaccine by forcing a type of human ovarian cancer cell line to produce interleukin-2, an immune system chemical. The cells were injected into some laboratory mice, while others received injections of cells from a related cancer. Mice that received the cellular vaccine lived longer than mice that did not, and tumors disappeared in 25% of the vaccinated mice. The cells were eventually killed by high-dose radiation, but not by moderate doses. The vaccine may work by inducing the immune system to respond to the interleukin-2 tumor cells. Development of cancer vaccines derived from a patient's own cancer may have advantages over current vaccines.

Physiological aspects, Cancer cells, Interleukin-2, Ovarian tumors

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Estrogen replacement in surgical stage I and II endometrial cancer survivors

Article Abstract:

Estrogen replacement therapy may not be contraindicated in women who have survived stage I or II endometrial cancer. The endometrium is the inner layer of the uterus. Researchers reviewed the outcomes of 123 women treated for stage I and II endometrial cancer, 62 of whom took estrogen replacement therapy after cancer treatment. Women who took estrogen had a similar death rate from recurrences of endometrial cancer (1.6%) as women who did not take estrogen. Estrogen therapy lowers the risk of cardiovascular disease and osteoporosis, both of which may outweigh the risk of cancer recurrence.

Health aspects, Risk factors, Cancer, Endometrial cancer, Estrogen, Estrogens, Cancer survivors, Cancer recurrence

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