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Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury

Article Abstract:

Research indicates a protective role for carbon monoxide in vascular injury by preventing arteriosclerotic lesions occurring following aorta transplantation. Data show pre-exposure to 250 parts per million of carbon monoxide for 1 hour suppresses stenosis by inhibiting graft leukocyte infiltration/activation and smooth muscle cell proliferation.

Author: Smith, R. Neal, Liu, Fang, Otterbein, Leo E., Bach, Fritz H., Choi, Augustine M.K., Billiar, Timothy R., Zuckerbraun, Brian S., Haga, Manabu, Song, Ruiping, Usheva, Anny, Stachulak, Christiana, Bodyak, Natalya, Csizmadia, Eva, Tyagi, Shivraj, Akamatsu, Yorihiro, Flavell, Richard J., Tzeng, Edith, Soares, Miguel P.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
United States, Portugal, Industrial Gas Manufacturing, Industrial gases, Carbon Monoxide, Prevention, Drug use, Cell proliferation, Leukocytes, White blood cells, Fistula, Arteriovenous, Arteriovenous fistula

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Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

Article Abstract:

Carbon monoxide may have therapeutic potential as an anti-inflammatory agent. It inhibits the production of inflammatory cytokines in vitro and in vivo and increases the production of the anti-inflammatory cytokine interleukin-10.

Author: Davis, Roger J., Otterbein, Leo E., Bach, Fritz H., Alam, Jawed, Soares, Miguel, Lu, Hong Tao, Wysk, Mark, Flavell, Richard A., Choi, Augustine M.K.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Inflammation, Inflammation mediators

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Requirement for CD154 in the progression of atherosclerosis

Article Abstract:

CD40-CD154 signaling appears to be involved in the progression of atherosclerotic lesions. In mice who were homozygous for a CD154 gene mutation, atherosclerotic plaque area was reduced 550%.

Author: Flavell, Richard A., Grewal, Iqbal S., Gorelik, Leonid, Lutgens, Esther, Daemen, Mat J.A.P., De Muinck, Ebo D., Koteliansky, Victor E.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Development and progression, T cell antigen receptors, T cells, Atherosclerosis

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Subjects list: Physiological aspects, Carbon monoxide
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