Carminerin contributes to chrondrocyte calcification during endochondral ossification

Article Abstract:

The creation of experimental models of pathological endochondral ossification led to the observation of suppression of chondrocyte calcification during formation of osteoarthritic osteophytes, age-related ectopic ossification and healing of bone fractures in [Cst10.sup-/-] mice. Cultured [Cst10.sup.-/-] chondrocytes showed a reduction in calcification with activation of an SRY site in the promoter of the gene encoding nucleotide pyrophosphatase phosphodiesterase 1 (NNP1, encoded by Enpp1).

United States, Osteoarthritis, Calcification, Phosphodiesterases, Ossification

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Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice

Article Abstract:

A study is conducted to show that the ATP-gated P2X4 ion channel, which is expressed on endothelial cells and is encoded by P2X4 in mice very much affects the regulation of the physiological function of many tissues and organs in a body. The results prove that the ehdothelial P2X4 channels are very crucial to the flow-sensitive mechanisms regulating blood pressure and vascular remodeling, as they lead to a chronic decrease in the blood flow with the decreasing vessel size.

Japan, Risk factors, Vascular resistance, Glycocalyx

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Central control of bone remodeling by neuromedin U

Article Abstract:

A study showed neuromedin U (NMU)-deficient more salient in male mice than the female having high bone mass due to increase in bone formation. The findings suggest NMU to be the first central mediator of leptin-dependent regulation and could be helpful to treat the diseases involving low bone mass, like osteoporosis.

Care and treatment, Bones, Bone density, Osteoporosis, Leptin

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