Ceftriaxone-associated biliary complications of treatment of suspected disseminated Lyme disease - New Jersey, 1990-1992

Article Abstract:

Long-term use of the antibiotic ceftriaxone by people infected with or suspected of being infected with Lyme disease may cause biliary (gall bladder) complications. Lyme disease is an inflammatory disorder transmitted to humans through a tick bite. Among 51 patients hospitalized for Lyme disease, 25 developed gallstones or other complications and 26 did not. All the patients who developed biliary complications had been treated with intravenous ceftriaxone within the 90 days of the onset of symptoms, compared with 58% of those who did not develop biliary complications. Ceftriaxone is the recommended drug therapy for patients with Lyme disease. Ceftriaxone may form a precipitate in the gallbladder. Patients undergoing treatment with ceftriaxone who develop pain in the area of the gall bladder or bile ducts should undergo ultrasonography to determine whether ceftriaxone precipitates have formed.

Complications and side effects, Lyme disease, Gallbladder, Rocephin (Medication)

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Treatment of streptococcal endocarditis with a single daily dose of ceftriaxone sodium for 4 weeks: efficacy and outpatient treatment feasibility

Article Abstract:

Fifty-five patients with streptococcal endocarditis were successfully treated with a single dose of ceftriaxone sodium every day for four weeks. Four patients had an adverse reaction to the drug and were switched to penicillin. Eight patients had to have a heart valve replaced, but in seven, the valve was not infected. Some patients showed no sign of infection up to five years after treatment. The American Heart Association recommends several doses of antibiotics every day by intravenous infusion or intramuscular injection, which usually requires hospitalization. A single dose would allow patients to be treated in outpatient clinics.

Health aspects, Endocarditis, Bacterial, Bacterial endocarditis, Ceftriaxone sodium

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Outbreak of group A streptococcal pneumonia among Marine Corps recruits -- California, November 1-December 20, 2002

Article Abstract:

The largest outbreak of group A streptococcal pneumonia in the US since 1968 occurred at the San Diego, California Marine Corps Recruit Depot during November and December of 2002. Thirty-one out of 128 Marines with pneumonia were infected with group A streptococci. This type of infection is rare in most towns and cities but more likely to happen at a military training facility where many people come from all parts of the country and work and live in crowded conditions.

California, Diseases, Pneumonia, Marines, Bacterial pneumonia

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