Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo

Article Abstract:

This article describes a methodology for increasing virally mediated gene delivery and the resulting protein expression in cells in vitro and in vivo using cell-permeable peptides. Small polybasic peptides such as alpha-helix of the Antennapedia homeodomain increase viral entry, improve gene and protein expession, and enhance efficacy of therapeutic genes in vivo.

Science & research, Protein synthesis, Gene expression, Protein biosynthesis, Genetic transformation

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Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies

Article Abstract:

Research on immunoglobulin frameworks reveals peptides function as killer cells often found in B-cell diseases. Issues discussed include clinical vaccinations against tumors, autologous cytotoxic T lymphocytes and human-leukocyte-antigens used to kill malignant B-cells, which may lead to new vaccinations against these types of diseases.

Cell-mediated cytotoxicity, Cell mediated cytotoxicity, B cells, Antigenic determinants

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F(ab)'(sub)2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins

Article Abstract:

Therapeutic doses of exogenous immunoglobulins inactivate the anaphylatoxins C3a and C5a by the latter binding to the former via the constant region of F(ab)'(sub)2 fragment, leading to the inhibition of anaphylatoxin-inducedpro-inflammatory events.

Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Immunotoxins, Analysis, Protein binding, Antigen-antibody reactions, Antibody-toxin conjugates

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