Characterisation of anticytoplasmic antibodies and their clinical associations

Article Abstract:

Cytoplasmic immunofluorescent staining patterns for antibodies to cellular components in patients with rheumatoid diseases may signify immune reaction to proteins of the cell's nucleus. The antinuclear antibody (ANA) test for antibodies to proteins in the cell's nucleus is one diagnostic test given to patients with autoimmune diseases. Blood serum samples from 1173 patients with such diseases as systemic lupus erythematosus, rheumatoid arthritis, or scleroderma were incubated with cultured human skin cells. The skin cells were then stained to reveal the presence of antibodies to cellular components and viewed under the microscope. Overall, 6.4% of patients displayed staining patterns in the cytoplasm. Of samples from 33 patients with cytoplasmic staining who were ANA negative, a further assay of the exact antigen found that five were positive for antigens found in the nucleus but which may also be found in the cytoplasm.

Anticytoplasmic antibodies

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Rheumatoid factors: where are we now?

Article Abstract:

More research is needed to determine why rheumatoid factor (RF) can become involved in rheumatoid arthritis. RF is a naturally produced antibody against immunoglobulins, particularly IgG and IgM. This puts it in the class of antibodies called autoantibodies. Its normal function is to bind to antigen-antibody complexes and remove them. This is a beneficial action and yet RF appears to play a destructive role in rheumatoid arthritis and other autoimmune disorders.

Rheumatoid factor

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HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27

Article Abstract:

The article presents an analysis of results found in a meta-search on spondylarthropathy, which is typically characterized as an autoimmune disease, a classification which the author calls into question. The issue is that the particulars of the interaction between human histocompatibiltiy antigen B27 (HLA-B27) and bacteria does not support the belief that it is an autoimmune disease.

Statistical Data Included, Bacteria, HLA histocompatibility antigens, HLA antigens

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