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Characteristics of prostate cancer in families potentially linked to the hereditary prostate cancer 1 (HPC1) locus

Article Abstract:

Men with a family history of prostate cancer should be screened for a mutation of the hereditary prostate cancer 1 (HPC1) gene so they can receive treatment during the early stages of the cancer. Researchers used genetic analysis to identify which of 74 families with hereditary prostate cancer might have an HPC1 mutation and whether their cancer had different characteristics than those who did not have the mutation. Overall, the cancers were similar except that men with the mutation got cancer at an earlier age and tended to have advanced disease.

Author: Trent, Jeffrey M., Walsh, Patrick C., Meyers, Deborah A., Carpten, John D., Gronberg, Henrik, Xu, Jianfeng, Isaacs, Sarah D., Smith, Jeffrey R., Bova, G. Steven, Freije, Diha, Collin, Francis S., Isaacs, William B,
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1997
Health aspects, Analysis, Gene mutations, Gene mutation, Phenotype, Phenotypes

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Prostate cancer

Article Abstract:

Genetics, lifestyle, and diet probably contribute to the development of prostate cancer in most men. Carcinogens in cooked meats may be a risk factor and vegetables may prevent prostate cancer. Research has also shown that infection or inflammation in the prostate may be a precursor of prostate cancer. Genes associated with prostate cancer include RNASEL, MSR1, AR, CYP17, SRD5A2, GSTP1, NKX3.1, PTEN, and CDKN1B.

Author: Nelson, William G., De Marzo, Angelo M., Isaacs, William B.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
Risk factors, Nutritional aspects

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Cumulative association of give genetic variants with prostate cancer

Article Abstract:

A study to ascertain the role of single-nucleotide polymorphisms (SNPs) in the development of prostate cancer was conducted. Results confirmed that family history coupled with SNPs in five chromosomal regions posed a higher risk of developing the cancer.

Author: Adami, Hans-Olov, Duggan, David, Bleecker, Eugene R., Meyers, Deborah A., Isaacs, William B., Carpten, John D., Ge Li, Zheng, S. Lilly, Sun, Jielin, Wiklund, Fredrik, Smith, Shelly, Stattin, Par, Fang-Chi Hsu, Yi Zhu, Balter, Katarina, Kader, A. Karim, Turner, Aubrey R., Liu, Wennuan, Bao-Li Chang, Jianfeng Xu, Gronberg, Henrik
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2008
United States, Science & research, Research, Single nucleotide polymorphisms, Clinical report

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Subjects list: Genetic aspects, Prostate cancer
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