Chronic kidney disease and the public health: Gaps in evidence from interventional trials

Article Abstract:

The impact of interventional trials on chronic kidney disease (CKD) and the public health is discussed. The National Institutes of Health (NIH) should give consideration to developing a durable clinical trials network focused on outcome-based interventional trails for population with advanced CKD and end-stage renal disease (ESRD).

Management dynamics, Labor Distribution by Employer, Management, Statistics, Clinical trials, Company business management

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Apolipoprotein E and progression of chronic kidney disease

Article Abstract:

The risk of chronic kidney disease progression associated with apolipoprotein E gene (APOE) in a population-based study including white, African American, diabetic, and nondiabetic individuals is quantified. APOE variation predicts chronic kidney disease progression, independent of diabetes, race, lipid, and nonlipid risk factors.

Health aspects, Risk factors, Apolipoproteins

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Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension

Article Abstract:

The pharmacogenetc relationship of the NPPA T2238C genetic variant with the cardiovascular disease outcomes in patients with hypertension is discussed. Patients with different alleles are found to exhibit different outcomes on being treated with different medications.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Blood Pressure Preparations, Hypertension, Cardiovascular diseases, Patient outcomes, Complications and side effects, Dosage and administration, Antihypertensive drugs, Antihypertensive agents, Clinical report

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