Cigarette smoking, bacterial pneumonia, and other clinical outcomes in HIV-1 infection

Article Abstract:

Cigarette smoking by HIV-infected patients appears to lower the risk of certain opportunistic infections and raise the risk of others. Researchers studied the effects of smoking in 3,221 HIV-positive men and women. Overall, 57% were smokers, 19% were former smokers and 24% had never smoked. There was no significant difference overall in the incidence of opportunistic infections between smokers and nonsmokers. However, smokers had a higher risk of pneumonia, oral candidiasis and AIDS dementia. They had a lower risk of Kaposi's sarcoma and other diseases outside the respiratory tract.

Health aspects, Complications and side effects, Risk factors, HIV infection, HIV infections, Smoking, Pneumonia, Opportunistic infections

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Prechallenge high neutralizing antibodies and long-lasting immune reactivity to gp41 correlate with protection of Rhesus monkeys against productive simian immunodeficiency virus infection or disease development

Article Abstract:

A vaccine made of gp130 oligomers from the sivian immunodeficiency virus (SIV) appears to be effective in protecting Rhesus monkeys from SIV infection. SIV is a virus similar to HIV that infects monkeys and creates a disease similar to AIDS. Researchers vaccinated Rhesus monkeys with a vaccine made from SIV gp130 oligomers or one made from SIV gp130 monomers. Then the monkeys were infected with SIV, as was a group of monkeys that were not vaccinated. Only the monkeys vaccinated with SIV gp130 oligomers were protected from infection.

Testing, AIDS vaccines, Simian immunodeficiency virus

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