The relationship between spontaneous rupture of membranes, labor, and microbial invasion of the amniotic cavity and amniotic fluid concentrations of prostaglandins and thromboxane B2 in term pregnancy

Article Abstract:

Levels of prostaglandins in amniotic fluid rise during spontaneous membrane rupture in the absence of labor and during spontaneous rupture in early labor. Prostaglandins are hormone-like substances that have been associated with the beginning of labor in mammals. A relationship between infectious organisms in the amniotic cavity and an increased level of prostaglandins was not found. Women who were either in labor or whose membranes had ruptured had amniocentesis performed. They were then divided into five groups according to whether they were in labor or not, whether or not their membranes had ruptured and whether there was evidence of infection. The presence of prostaglandins was determined by radioimmunoassay. Women whose pregnancy was full term and whose membranes ruptured spontaneously, even when they were not in labor, had a significant increase in prostaglandin levels in the amniotic fluid.

Analysis, Measurement, Prostaglandins, Labor (Obstetrics), Amniotic fluid

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Genome-wide expression profiling of fetal membranes reveals a deficient expression of proteinase inhibitor 3 in premature rupture of membranes

Article Abstract:

A genome-wide approach was used to identify differentially expresses genes in patients with premature rupture of membranes to improve the understanding of molecular mechanisms. This approach identified deficient expression of proteinase inhibitor 3.

Science & research, Causes of, Risk factors, Gene expression, Premature rupture of membranes, Premature rupture of the membrane, Premature labor, Premature labour

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