Clinical relevance of gastrointestinal hormones: emerging interest in hypergastrinemia

Article Abstract:

Infection of the stomach by the bacterium Helicobacter pylori may increase the secretion of gastrin and cause the development of peptic ulcer disease or stomach cancer. Gastrin is a gastrointestinal hormone that increases the secretion of stomach acid following a meal. Infection with Helicobacter pylori causes hypergastrinemia, or increased secretion of gastrointestinal hormones such as gastrin. This causes increased secretion of stomach acid and may lead to the development of a peptic ulcer. Treating patients with a Helicobacter pylori infection does not always reduce gastrin levels or secretion of stomach acid. Helicobacter pylori infections have also been associated with certain types of stomach cancer. Increased secretion of gastrin may affect the lining of the stomach and increase cell proliferation. Patients suffering from hypergastrinemia may also have a higher risk of other types of cancer.

Editorial, Helicobacter infections, Gastrin

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A clinical and immunologic evaluation of women with silicone breast implants and symptoms of rheumatic disease

Article Abstract:

The association between silicon breast implants and rheumatic disease as determined by blood tests appears to be rare. Of 156 women with breast implants and complaints of rheumatic disease, 95 had joint and muscle pain, 32 had joint swelling and 29 had connective tissue disease. The control group included women who had breast implants but no symptoms of rheumatic disease and women who had symptoms but no implants. Women with joint pain or swelling had normal serological findings and did not differ from women in the control group. Women with connective tissue diseases had significantly higher immunoglobulin levels than all of the other groups. Western blot testing indicated that 14 of these women had findings indicative of a scleroderma-like illness and 15 had findings consistent with other connective tissue diseases.

Causes of, Rheumatic diseases, Breast implants

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