Coexpression of virulence and fosfomycin susceptibility in Listeria: Molecular basis of an antimicrobial in vitro-in vivo paradox

Article Abstract:

A study demonstrates that discrepancies between resistance in vitro and therapeutic efficacy in vivo can result from differential in vitro-in vivo expression of bacterial determinants of antibiotic susceptibility. Results show that an in vivo-induced virulence factor, Hpt, also mediates uptake of fosfomycin in Listeria monocytogenes, which seem resistant to fosfomycin in vitro, although they are in fact susceptible to the antibiotic during infection.

Science & research, Genetic aspects, Virulence (Microbiology), Listeria monocytogenes, Fosfomycin

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In vivo veritas: the search for TB drug targets goes live

Article Abstract:

An analysis is presented on factors enabling tuberculosis microorganisms to survive inside the body despite having displayed drug susceptibility in tests performed outside the body. These include the bacteria's physiologic heterogeneity in the tissues, and the presence of a gene cluster which regulates the export and synthesis of phthiocerol dimycocerosate, a complex cell wall-associated lipid.

Physiological aspects

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The death and resurrection of tuberculosis

Article Abstract:

A DNA vaccine based on the heat shock protein of Mycobacterium tuberculosis could be an effective treatment for tuberculosis. It may be beneficial in those with active infection and may prevent activation of the organism in those with latent infection.

Health aspects, Care and treatment, Bacterial vaccines

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