In vivo imaging of siRNA delivery and silencing in tumors

Article Abstract:

Dual-purpose probes are developed for in vivo transfer of siRNA and simultaneous imaging of its accumulation in tumors by high-resolution magnetic resonance imaging (MRI) and near-infrared in vivo optical imaging (NIRF). This new approach might advance siRNA delivery and imaging strategies, which are essential for cancer therapeutic product development and optimization.

Science & research, Usage, Toxicity testing, In vitro tests, RNA interference

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In vivo molecular target assessment of matrix metalloproteinase inhibition

Article Abstract:

Research has been conducted on the matrix metalloproteinase inhibitors. The development of these inhibitors as the cytostatic and anti-angiogenic agents has been carried out and they are being currently clinically tested.

Statistical Data Included, Analysis, Physiological aspects, Medical research, Metalloenzymes, Pharmaceutical research

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In vivo magnetic resonance imaging of transgene expression

Article Abstract:

Transgene expression has been observed in living mice by magnetic resonance imaging. The technique developed through this study suggests cell surface proteins could be used to image and detect tumors in humans.

Measurement, Gene expression

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