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Combined pharmacotherapies and behavioral interventions for alcohol dependence

Article Abstract:

A study to evaluate the efficacy of medication, behavioral therapies, and their combinations for treatment of alcohol dependence and to evaluate placebo effect on overall outcome is presented. A positive effect of receiving placebo medication and medical management over and above that seen with specialist-delivered behavioral therapy alone is observed and so medical management of alcohol dependence with naltrexone appears to be feasible.

Author: Randall, Carrie L., Johnson, Bankole A., Donovan, Dennis M., O'Malley, Stephanie S., Swift, Robert, Pettinati, Helen M., Mattson, Margaret E., Ciraulo, Domenic A., Gastfriend, David R., Longabaugh, Richard, Miller, William R., Weiss, Roger D., Anton, Raymond F., Cisler, Ron A., Couper, David, Hosking, James D., Mason, Barbara J., Williams, Lauren D., Zweben, Allen
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2006
Science & research, Care and treatment, Research, Patient outcomes, Placebos, Placebo effect

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Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence

Article Abstract:

The efficacy and tolerability of a long-acting intramuscular formulation of naltrexone for treatment of alcohol-dependent patients is determined. Results revealed that the long-acting naltrexone was well tolerated and resulted in reductions in heavy drinking among treatment-seeking alcohol-dependent patients during 6 months of therapy.

Author: Kranzler, Henry R., O'Malley, Stephanie S., Pettinati, Helen M., Gastfriend, David R., Garbutt, James C., Silverman. Bernard L., Loewy, John W., Ehrich, Elliot W.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
United States, Usage, Naltrexone, Alcoholics

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Topiramate for treating alcohol dependence: a randomized controlled trial

Article Abstract:

A study investigates if topiramate is a safe and effective treatment for alcohol dependence. Results show that topiramate is significantly efficacious in treating alcohol dependence.

Author: Johnson, Bankole A., Ait-Daoud, Nassima, Kranzler, Henry R., O'Malley, Stephanie S., Ciraulo, Domenic A., Rosenthal, Norman, Anton, Raymond F., Capece, Julie A., Wiegand, Frank, Lian Mao, McKay, Amy, Beyers, Karen, Mann, Karl, Swift, Robert M.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
Individual and family services, Other Individual and Family Services, Alcoholics Rehabilitation, Alcoholism treatment, Dosage and administration, Topiramate, Clinical report

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Subjects list: Alcoholism, Drug therapy
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