Comparison of manual and automated cell counts in EDTA preserved synovial fluids: storage has little influence on the results

Article Abstract:

It appears that automated methods used to count cells in synovial fluid (SF) samples may be more preferable than those done manually. Two automated and two manual techniques were used repeatedly to count cells in 100 SF samples. Results were compared for accuracy and variability. The two automated techniques provided more consistently accurate results, particularly in samples with high cellular concentrations. Results were significantly different when comparing the two methods. Storage temperature variations did not affect the automated results as significantly as they did the manual results.

Measurement, Leukocytes, White blood cells

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Synovial Fluid Analysis for Diagnosis of Intercritical Gout

Article Abstract:

Examining synovial fluid samples for the presence of monosodium urate crystals can be used to detect gout in asymptomatic patients with a history of gout. This technique can also be used to monitor the effects of therapy. Gout is caused by deposits of monosodium urate crystals in the joint of the big toe. Researchers took synovial fluid samples from 91 people with a history of gout but who were asymptomatic. Microscopic examination revealed crystals in all 43 patients who were not treated and in 34 of 48 patients who were treated.

Diagnosis, Medical examination, Gout, Uric acid

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Most calcium pyrophosphate crystals appear as non-birefringent

Article Abstract:

The authors discuss how well polarized light will show calcium diphosphate dihydrate crystals (CPPD) when viewed under a microscope. Calculating the amount of CPPD in synovial fluid helps in diagnosis, but only about 20% was visible in these tests.

Statistical Data Included, Methods, Metallography

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• Abstracts: Long term persistent accumulation of CD8+ T cells in synovial fluid of rheumatoid arthritis. Type II collagen is a target antigen of clonally expanded T cells in the synovium of patients with rheumatoid arthritis

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