Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury

Article Abstract:

Study is presented to show that reactive astrocytes have a crucial role in wound healing and functional recovery by using mice with a selective deletion of the protein signal transducer and activator of transcription 3 (Stat3) or the protein suppressor of cytokine signaling 3 (Socs3) under the control of the Nes promoter-enhancer. The results suggest that Stat3 is a key regulator of reactive astrocytes in the healing process after spinal cord injury, providing a potential target for intervention in the treatment of central nervous system injury.

Health aspects, Astrocytes, Ablation (Surgery)

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Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury

Article Abstract:

The activation of the caspase-3 cascade may explain why spinal cord injury damages nerves at sites far from the actual injury. Caspase-3 is part of a family of proteases that regulates apoptosis. In a study of rats, caspase-3 was activated early at the site of the injury and hours to days later at sites distant from the injury.

Physiological aspects, Cell death

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Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

Article Abstract:

Embryonic stem cell transplants may be beneficial in treating spinal cord injury. In a study of mice with spinal cord injury, the cells differentiated into astrocytes, oligodendrocytes and neurons and restored function in the rats' hind legs.

Stem cells, Stem cell transplantation

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