Conventional-dose chemotherapy compared with high-dose chemotherapy plus autologous hematopoietic stem-cell transplantation for metastatic breast cancer

Article Abstract:

High-dose chemotherapy and hematopoietic stem cell transplants do not appear to be beneficial in women with advanced breast cancer. Researchers randomly assigned 199 women with advanced breast cancer who had a response to chemotherapy to continue receiving normal doses of chemotherapy or high-dose chemotherapy plus a hematopoietic stem cell transplant. Hematopoietic stem cells are the precursors of all blood cells and are used to replenish the immune system, which is often damaged by chemotherapy. However, survival rates and disease progression rates were similar in both groups of women in this study.

Hematopoietic stem cells

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Conventional adjuvant chemotherapy with or without high-dose chemotherapy and autologous stem-cell transplantation in high-risk breast cancer

Article Abstract:

High-dose chemotherapy followed by a blood stem cell transplant is no more effective than traditional chemotherapy for treating women with breast cancer that has spread to 10 or more lymph nodes, according to a study of 511 women. Women with such widespread cancer have the highest rates of relapse after traditional chemotherapy. These women received a blood stem cell transplant because high-dose chemotherapy damages the immune system.

Evaluation, Lymphatic metastasis

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HER2 and response to paclitaxel in node-positive breast cancer

Article Abstract:

A study aims to examine the benefit from adjuvant doxorubicin on human epidermal growth factor receptor type 2 (HER2) in breast cancer cells. The results concluded no interaction between HER2 positivity and doxorubicin but it did react to paclitaxel.

Paclitaxel, Doxorubicin, Clinical report

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