Correlation of genetic and serologic approaches to HIV-1 subtyping in Thailand

Article Abstract:

Enzyme-linked immunosorbent assay (EIA) and the polymerase chain reaction (PCR) appear to be almost as effective as other assays for subtyping HIV-1. Researchers evaluated three different assay techniques on blood samples from 38 HIV-infected individuals: EIA, PCR and the heteroduplex mobility assay (HMA). PCR correctly identified the viral subtype in 100% of the samples typed by HMA. EIA correctly identified the viral subtype in 95% of the samples typed by HMA. EIA and PCR are simpler and less time-consuming than HMA.

Viruses, Identification and classification, Virology

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Genetic, antigenic and serologic characterization of human immunodeficiency virus type 1 from Indonesia

Article Abstract:

HIV-1 subtype B appears to be the predominant strain of HIV-1 in Indonesia although subtype E may also occur. Researchers used various tests to determine the viral subtype in 19 HIV-positive people. Twelve were infected with subtype B and 7 were infected with subtype E. However, 6 of the 7 infected with subtype E had been on a peacekeeping mission in Cambodia. Their viral strain was neutralized by antibodies against the Thailand E subtype. It is possible that they contracted the infection while in Thailand.

Health aspects, Demographic aspects, HIV infection, HIV infections, Indonesia

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Safety and immunogenicity of HIV recombinant envelope vaccines in HIV-infected infants and children

Article Abstract:

AIDS vaccines made from the HIV gp120 or gp 160 protein appear to be safe enough to use in infants and children. Researchers vaccinated 72 HIV-infected children between one month and 18 years old with a gp120 vaccine, a gp160 vaccine, or a placebo approximately every month for about six months. Sixty-five percent of those who received the vaccine developed an immune response to it, which did not occur in the placebo group.

Testing, Prevention, HIV infection in children, Pediatric HIV infections, AIDS vaccines

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