Cyclohexanehexol inhibitors of A(beta) aggregation prevent and reverse Alzheimer phenotype in a mouse model

Article Abstract:

Cyclohexanehexol stereoisomers, when given orally to a transgenic mouse model of Alzheimer disease, inhibit aggregation of amyloid beta peptide into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease-like phenotypes in these mice including impaired cognition, altered synaptic physiology, cerebral A(beta) pathology and accelerated mortality. These therapeutic effects suggest that accumulation of A(beta) oligomers has significant role in the pathogenesis of Alzheimer disease.

Industrial Organic Chemicals, Cyclic Crude and Intermediate Manufacturing, Inositol, Health aspects, Prevention, Alzheimer's disease

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Fighting arthritis with a senescence gene

Article Abstract:

The senescent phenotype can be restored by the p16(super.INK4a) tumor suppressor gene and is repressed in rheumatoid arthritis. Rheumatoid arthritis is one of many diseases likely triggered by inflammatory injury but sustained by abnormal proliferation of connective tissue cells. Repression of the p16(super.INK4a) senescence mechanism may be a general one to sustain connective tissue hyperplasia.

Physiological aspects, Genetic aspects, Rheumatoid arthritis, Tumor suppressor genes

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Modeling epidemics of multidrug-resistant M.tuberculosis of heterogeneous fitness

Article Abstract:

Mathematical models are used to predict the future burden of multidrug-resistant tuberculosis (MDRTB). Multidrug resistant in M. tuberculosis is conferred by the sequential acquisition of a number of different single-locus mutations that are shown to have heterogeneous phenotypic effects.

Tuberculosis

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