Effects of nabumetone compared with naproxen on platelet aggregation in patients with rheumatoid arthritis

Article Abstract:

Naproxen seems to be much more effective than nabumetone in inhibiting platelet aggregation in patients with rheumatoid arthritis (RA). Given that many RA patients require non-steroidal anti-inflammatories, those with an increased risk of bleeding might find this difference relevant. In a crossover study of 10 patients, all patients used one anti-inflammatory or the other for two weeks, did a cleaning-out period for two weeks, then used the other for two weeks. Platelet aggregation was studied and bleeding time measured before and after each period of treatment.

Evaluation, Blood platelets, Cell aggregation, Naproxen, Nabumetone

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Anti-inflammatory effects of systemic anti-tumour necrosis factor alpha treatment in human/murine SCID arthritis

Article Abstract:

Antibodies against tumor necrosis factor alpha reduce joint swelling and serum amyloid P levels, and increase serum interleukin 6 levels in severely immunodeficient (SCID) mice bearing a human gene for rheumatoid arthritis synovial membrane.

Germany, Health aspects, Statistical Data Included, Monoclonal antibodies, Tumor necrosis factor

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