Daytime reduction of gastro-oesophageal reflux after healing of oesophagitis and its value as an indicator of favourable response to maintenance treatment

Article Abstract:

Gastroesophageal reflux is a condition in which highly acidic gastric contents are regurgitated into the esophagus. This causes a painful ulceration of the esophagus (esophagitis), and can have serious consequences. Assessment of the healing process is usually evaluated by means of endoscopy, in which a fiber optic viewing device is used to examine the esophageal wall. It is becoming clear that the drug-induced disappearance of visible ulceration of the esophagus does not correspond to relief of painful symptoms in all cases. Motility dysfunction, high levels of acid in the esophagus, and other underlying events may continue after pain subsides. This continuation may be at least partially to blame for the frequent relapses seen in patients receiving drug therapy (compared with surgical treatment, which normalizes both the painful symptoms and the ulceration of the esophagus). The most sensitive test for normalized esophageal function seems to be monitoring of esophageal pH (acidity), especially when measurements are made over a 24-hour period. To investigate the prevalence of gastroesophageal reflux after drug-induced healing of esophagitis, and to ascertain whether or not reflux has any value in predicting relapse, a study was carried out in 20 patients with reflux esophagitis who were treated with ranitidine (a histamine blocker that suppresses gastric acid secretion). Twenty-four hour esophageal pH monitoring and endoscopic evaluation of esophageal status were done both before and after drug treatment. Significant healing of esophageal ulcers was seen in all patients following drug treatment. The incidence and severity of reflux episodes were reduced in some patients during waking hours, but no changes were observed in night-time reflux. During maintenance treatment, five of the six patients who had not shown an improvement in reflux episodes experienced relapse, whereas none of those who had improved relapsed. It is concluded that the occurrence of a reduction in gastroesophageal reflux is predictive of a good response to long-term treatment. (Consumer Summary produced by Reliance Medical Information, Inc.)

Care and treatment, Prevention, Physiological aspects, Prognosis, Gastroesophageal reflux, Antiulcer agents, Antiulcer drugs

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Bax translocation and mitochondrial fragmentation induced by Helicobacter pylori

Article Abstract:

The occurrence of bax translocation and mitochondrial fragmentation on exposure of gastric epithelial cells to helicobacter pylori is discussed. Bax translocates to the mitochondria during helicobacter pylori induced apoptosis resulting in subsequent depolarization and profound segmentation.

Mitochondrial DNA, Translocation (Genetics), Translocations (Genetics)

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H pylori infection and reflux oesophagitis

Article Abstract:

Helicobacter pylori results in the pathogenesis of gastro-oesophageal reflux disease (GORD). The eradication of helicobacter pylori helps in controlling (GORD) symptoms and improves oesophagitis.

Bacteria, Pathogenic, Pathogenic bacteria, Genetic research

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