Direct comparison of the acute in vivo effects of HIV protease inhibitors on peripheral glucose disposal

Article Abstract:

The acute effects on protease inhibitors (Pls) on peripheral glucose disposal in a rodent model system in which serum drug levels, genetic background, and environment can be tightly controlled was investigated in order to compare the relative potency of various Pls to induce insulin resistance in vivo. It was found that the in vivo potency of PIs to impair peripheral glucose disposal acutely correlates with the degree of insulin resistance observed in HIV-infected patients receiving the drugs.

Medical examination, HIV patients, Glucose, Glucose synthesis

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An increase in viral replicative capacity drives the evolution of protease inhibitor-resistant human immunodeficiency virus type 1 in the absence of drugs

Article Abstract:

In vitro evolution experiments are performed in the absence of drugs with a unique panel of six drug-resistant human immunodeficiency virus type-1 recombinant protease variants with a range of different replicative capacity (RC), which is used to examine if viral RC is an important determinant. The experiments revealed that an increase in viral RC is indeed an important determinant of evolution.

Analysis, HIV (Viruses), HIV, Drug resistance, Clinical report

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Transport of HIV protease inhibitors through the blood-brain barrier and interactions with the efflux proteins, P-glycoprotein and multidrug resistance proteins

Article Abstract:

The cerebral uptake of HIV protease inhibitors and their interactions with efflux proteins is discussed. The limited penetration of the HIV protease inhibitors (HPIs) is due to active efflux of proteins like P-glycoprotein, which prevents drugs from clearing the brain of the virus.

Usage, AIDS (Disease), AIDS research

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