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Decreased selenium levels in acute myocardial infarction

Article Abstract:

Selenium is an essential mineral. Deficiency of selenium in the body may lead to cardiomyopathy, a general term for disease of the heart muscle. The relationship between selenium levels in various parts of the body and the risk of heart attack (myocardial infarction) was studied. Selenium levels were measured in the blood and in the toenails of patients who had suffered a heart attack, as well as in a group of healthy subjects (controls). The selenium content in a toenail reflects the level of selenium content in the blood up to one year prior. The healthy group had lower average levels of selenium than the patients who had suffered a heart attack. Lower levels of selenium in the toenail indicated a greater risk of heart disease. Low selenium levels detected in toenail samples suggest that the patients had selenium deficiency in the blood before the heart attack.

Author: Hofman, Albert, Witteman, Jacqueline C.M., Kok, Frans J., de Bruijn, Anthony M., Kruyssen, Dick H.C.M., Bruin, Marcel de, Valkenburg, Hans A.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1989
Risk factors, Physiological aspects, Heart attack, Health risk assessment, Selenium, Selenium (Chemical element)

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Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction

Article Abstract:

Genetic variations in the estrogen receptor alpha (ESR1) gene may influence ischemic heart disease (IHD) risk, but the role of common sequence variations in the ESR1 gene is unclear. Whether the ESR1 haplotype created by the c.454397T>C (Pvull) and c.454-351A>G (Xbal) polymorphisms is associated with myocardial infarction (MI) and IHD risk is examined.

Author: Hofman, Albert, Witteman, Jacqueline C.M., Zillikens, M. Carola, Uitterlinden, Andre G., Schuit, Stephanie C., Oei, Hok-Hay S., Kessel, Corine H. Geurts van, Meurs, Joyce B.J. van Leeuwen, Jong, Frank H. de, Pols, Huibert
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
Science & research, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Estrogen & Progestogen Preps, Care and treatment, Heart diseases, Genetic polymorphisms, Estrogen, Estrogens

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Dietary intake of antioxidants and risk of age-related macular degeneration

Article Abstract:

A study aims to investigate whether regular dietary intake of antioxidants is associated with a lower risk of incident age-related macular degeneration (AMD). A high dietary intake of beta-carotene, vitamins C and E, and zinc is associated with a substantially reduced risk of AMD in elderly persons.

Author: Hofman, Albert, Witteman, Jacqueline C.M., Leeuwen, Redmer van, Boekhoorn, Sharmila, Vingerling, Johannes R., Klaver, Caroline C.W., Jong, Paulus T.V.M. de
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
Health aspects, Antioxidants, Antioxidants (Nutrients), Diet therapy, Macular degeneration

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Subjects list: Research, United States
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