Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

Article Abstract:

The protein p27(super Kip1) progressively accumulates in the nucleus of pancreatic beta cells in mice that like either insulin receptor substrate 2 or the long form of the leptin receptor. Deletion of the gene encoding p27(super Kip27) ameliorated hyperglycemia in these animal models of type 2 diabetes mellitus by increasing islet mass and maintaining compensatory hyperinsulinemia effects.

United States, Science & research, Protein research, Mice as laboratory animals, House mouse, Hyperglycemia, Metabolic diseases

---

High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation

Article Abstract:

NF-kappaB appears to be essential for normal liver function. When its activity was blocked in mice, they were unable to clear a Listeria infection from the liver. NF-kappaB inhibition has been proposed as a therapeutic agent.

Physiological aspects, Liver, Immune system, Disease susceptibility

---

Pancreatic and duodenal homeobox gene 1 induces experssion of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

Article Abstract:

The pancreatic and duodenal homeobox gene 1 (PDX-1) can re-program non-pancreatic tissues to produce insulin. This was done in mice, whose livers began producing functional insulin after gene transfer of PDX-1.

Genetic aspects, Gene expression, Homeobox genes, Insulin

Similar abstracts:

• Abstracts: Evaluation of postdoctoral physician-scientist training programs in obstetrics and gynecology. Is the academic physician-scientist an oxymoron in contemporary obstetrics and gynecology?
• Abstracts: Diet in relation to socioeconomic status in patients with coronary heart disease. Concordance of diet with the recommended cholesterol lowering diet in patients with coronary heart disease
• Abstracts: Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A
• Abstracts: Decision making by analogy. Bartonella (Rochalimaea) quintana bacteremia in inner-city patients with chronic alcoholism
• Abstracts: Survival of the fittest. Sexercise: a fit body leads to better sex

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.