Delivery of dehydroepiandrosterone to premenopausal women: effects of micronization and nonoral administration

Article Abstract:

Administration of an adrenal hormone known as dehydroepiandrosterone (DHEA) may be used to treat premenopausal women who do not produce enough adrenal hormones or who receive anti-inflammatory steroids. DHEA and DHEA-sulfate (DHEA-S) may protect the body against cancer, narrowing of arteries, and osteoporosis. Levels of these hormones are known to decrease with age. Researchers compared the effect of oral micronized DHEA to that of crystalline DHEA in seven premenopausal women. Higher blood levels of DHEA-S were associated with the micronized preparation, and DHEA-S was higher than DHEA or testosterone. Five premenopausal women received either oral or vaginal micronized DHEA. The oral micronized form of DHEA produced higher blood levels of DHEA and DHEA-S than did the vaginal form.

Aging, Physiological aspects, Drug delivery systems, Dosage and administration, Dehydroepiandrosterone

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Efficacy of superovulation and intrauterine insemination in the treatment of infertility

Article Abstract:

Superovulation and intrauterine insemination appears to be more effective in the treatment of infertility than many other methods. In this technique, the woman is given hormones to stimulate ovulation and then the man's sperm is injected into the uterus through the cervix. Researchers compared the pregnancy rates in 231 couples treated with this technique to the rates in 234 couples who received intrauterine insemination alone and two other groups of women who received their partner's sperm using other methods, with or without superovulation. Pregnancy rates were highest in the women who received superovulation and intrauterine insemination.

United States, Care and treatment, Infertility, Female, Female infertility, Artificial insemination, Human, Human artificial insemination

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Transdermal testosterone treatment in women with impaired sexual function after oophorectomy

Article Abstract:

A testosterone patch may benefit some women with impaired sexual function, according to a study of 75 women who had their ovaries removed before menopause. The ovaries produce testosterone naturally, and many women who have them removed have impaired sexual function even when treated with estrogen.

Health aspects, Sexual disorders, Drug therapy, Testosterone

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