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Design and use of conditional MHC class I ligands

Article Abstract:

Conditional major histocompatability complex (MHC) ligands for the generation of peptide-receptive MHC class I molecules are identified. Arrays of peptide ligands loaded onto empty MHC molecules help in the determination of MHC binding properties and for monitoring antigen-specific T-cell responses in high-throughput manner.

Author: Haanen, John B.A.G., Schumacher, Ton N.M., Rimmelzwaan, Guus F., Toebes, Mireille, Coccoris, Miriam, Bins, Adriaan, Rodenko, Boris, Gomez, Raquel, Nieuwkoop, Nella J., Kasteele, Willeke van de, Ovaa, Huib
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
Peptides, Histocompatibility, Atomic properties

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Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury

Article Abstract:

Therapeutic neutralization of CD95 ligand significantly decreased apoptotic cell death after spinal cord injury (SCI). The improvement in function was due to an increase in regenerating fibers and upregulation of growth-associated protein-43 (GAP-43).

Author: Krammer, Peter H., Demjen, Deana, Zuliani, Cecilia, Hirt, Ulrich A., Martin-Villalba, Ana, Klussmann, Stefan, Stieltjes, Bram, Walczak, Henning, Kleber, Susanne, Metzger, Corinna, Falk, Werner, Essig, Marco
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Spinal cord injuries

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NF-(kappa)B is activated and promotes cell death in focal cerebral ischemia

Article Abstract:

NF-(kappa)B has been found to be activated and to promote cell death in focal cerebral ischemia. In a rodent model of stroke, the role of NF-(kappa)B has been studied. NF-(kappa)B may provide a new pharmacological target in neurologic disease.

Author: Schneider, Armin, Martin-Villalba, Ana, Schwaninger, Markus, Weih, Falk, Vogel, Johannes, Wirth, Thomas
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Germany, Physiological aspects, Stroke (Disease), Stroke, Cell death, Rodents, Cerebral ischemia

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Subjects list: Research, United States, Ligands (Biochemistry)
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