The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy

Article Abstract:

A transcriptome analysis of a genetic mouse model of heart failure was conducted for delineating molecular determinants of cardiomyocyte hypertrophy and failure. NGFI-A binding protein (NAB1) and its target transcription factor early growth response-1 (Egr1) are important endogenous regulators of pathological cardiac growth.

Heart enlargement, Heart hypertrophy, Binding proteins

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The genetic basis for skeletal diseases

Article Abstract:

Many of the critical transcription factors and signaling pathways specifying the normal development of bones are identified by the recent study of rare genetic diseases. The details about the bone disorders and classification of skeletal diseases are discussed.

Bone development

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Breast cancer progression with a Twist

Article Abstract:

The probability to understand the tumor progression, in terms of the redeployment of mechanisms used in embryotic development, is analyzed. By studying the bHLH transcription factor, it is possible to identify the progress of tumors.

Development and progression, Breast cancer

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