Detection of virus-specific T cells and CD8(sup)+ T-cell epitopes by acquisition of peptide-HLA-GFP complexes; analysis of T-cell phenotype and fnction in chronic viral infections

Article Abstract:

The acquisition of peptide-HLA-GFP complexes by antigen-specific T-cells confer the ability on these cells to quantitatively identify epitope-specific T-cells and new CD8(sup)+ T-cell immunodominant epitopes from peripheral blood mononuclear cells. Data indicate that the system is applicable for phenotypic characterization and cell lysing activity measurements of virus-specific T-cells.

Virus diseases, CD8 lymphocytes

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T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation

Article Abstract:

Research shows that the immune activation in the T-cell-specific glucocorticoid receptor knockout mice results in their mortality, suggesting that the T-cell is an important cellular target of glucocorticoid receptor signaling. Data indicate that the lethal activation can be rescued by cyclooxygenase-2 (COX-2) inhibition.

Corticosteroids, Adrenocortical hormones, Cell receptors, Cyclooxygenases, Glucocorticoids

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Skin controls immune regulators

Article Abstract:

A study report provides explanation for the long-observed phenomenon that ultraviolet light suppresses the immune response in skin. The findings suggest that light and other stimuli prompt the proliferation of regulatory T cells through the upregulation of receptor activator of NF-B ligand (RANKL) on skin cells.

Science & research, Research, Cell proliferation

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