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B cell memory: sapping the T cell

Article Abstract:

Research reveals that the signaling lymphocytic activation molecule-associated protein is involved in the maintenance of antibody levels and memory B cells. The protein binds to the leukocytic receptors and inhibit the receptor interaction with tyrosine phosphatases. Deficiency in this protein leads to immune deficiency.

Author: Welsh, Raymond M., Szomolanyi-Tsuda, Eva, Stepp, Susan E.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Immunity, Immunity (Physiology), Viral antibodies, Antibodies

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Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

Article Abstract:

Research indicates that the interleukin-15 expanded T cells survive in tumor-bearing severe combined immunodeficiency-Beige mice and mediate eradication of the disseminated intramedullary tumors. Furthermore, transducer T cells from chronic lymphocytic leukemia can lyse autologous tumor cells.

Author: Latouche, Jean-Baptiste, Sadelain, Michel, Brentjens, Renier J., Santos, Elmer, Marti, Francesc, Gong, Michael C., Lyddane, Clay, King, Philip D., Larson, Steven, Weiss, Mark, Riviere, Isabelle
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Development and progression, Tumors, Survival after airplane accidents, shipwrecks, etc., Survival, Tumours, Interleukin-15

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Dengue immune response: low affinity, high febrility.

Article Abstract:

The immune response of the dengue virus infection is illustrated. Dengue is a mosquito-borne tropical disease caused by four major serotype viruses.

Author: Welsh, Raymond M., Rotham, Alan L.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Analysis, Causes of, Immune response, Dengue viruses, Dengue virus

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Subjects list: United States, Physiological aspects, B cells, T cells
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