Determinants of progression of HIV infection in a Greek hemophilia cohort followed for up to 16 years after seroconversion
Article Abstract:
Most HIV infected hemophiliacs in Greece develop AIDS symptoms or very low CD4 white blood cells levels within 15 years of infection. Researchers evaluated the progression of HIV infection among 158 men with hemophilia over 16 years. Seventy-two percent died during the course of the study, 30% from liver failure or bleeding in the brain. AIDS or a CD4 cell count below 200 cells/mm3 developed in 82% of patients. Patient who tested positive for HIV infection after age 40 were more likely to progress to AIDS, have a sharp decline in CD4 cell count, or die.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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No evidence of a higher risk of progression to AIDS in patients with HIV-1-related severe thrombocytopenia
Article Abstract:
Thrombocytopenia (TCP) appears to have no relationship to immunosuppression in HIV-infected patients and is not associated with the progression of the disease. Of 1,533 HIV-infected men and women, only 6% had severe TCP, which is the technical term for low blood levels of platelets. Five percent had moderate TCP and 16% had borderline TCP. Those with high CD4 counts were just as likely to have TCP as those with low counts. The risk of developing AIDS was actually higher in those with borderline to moderate TCP than those with severe TCP.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Determinants of progression to AIDS in HIV-infected individuals: an update from the Italian Seroconversion Study
Article Abstract:
The Italian Seroconversion Study (ISS) incorporates data on 1,200 HIV patients from 16 medical centers in Italy. Fifty-six percent of patients contracted HIV infection from intravenous drug use, 25% from male homosexual sexual contact, and 7% from heterosexual sex. Older patients and gay men experienced more rapid progression of the disease, and patients who began AZT (zidovudine) therapy within a year of diagnosis had a 38% lower risk of progression to AIDS.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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