Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus

Article Abstract:

The individual contact residues of 14 newly generated monoclonal antibodies are defined against domain III of the West Nile virus (WNV) E protein using random mutagenesis and yeast surface display. It is found that in postexposure therapeutic trials in mice, a single dose of humanized E16 protected mice against WNV-induced mortality, and may therefore be a viable treatment option against WNV infection in humans.

Monoclonal antibodies, Mutagenesis, West Nile virus

---

Inhaled CO: deadly gas or novel therapeutic?

Article Abstract:

Research presented concerns the novel use of poisonous gas carbon monoxide as an inhalation therapy to reduce the effects of acute lung injuries. Topics include brain metabolism of CO, the biological aspects of heme oxygenase, and the potential benefits of the upregulation of HO-1, as a protector of the lungs and associated tissues against oxidative stress.

Physiological aspects, Oxidation, Physiological, Physiological oxidation, Carbon monoxide, Respiratory therapy, Hemoproteins

---

Therapeutic effects of lysophosphatidylcholine in experimental sepsis

Article Abstract:

Studies reveal that administration of lysophosphatidylcholine (LPC), an endogenous lysopholipid, protected mice against lethality after cecal ligation and puncture (CLP) or intraperitoneal injection of Escherichia coli. LPC is used in the prevention and treatment of sepsis and infections.

Bacterial infections, Sepsis

Similar abstracts:

• Abstracts: Cost-effectiveness of monoclonal antibodies to gram-negative endotoxin in the treatment of gram-negative sepsis in ICU patients
• Abstracts: Protecting the patient at risk. Administering antibiotic therapy at home
• Abstracts: Current role of digitalis therapy in patients with congestive heart failure. Digitalis for treatment of congestive heart failure in patients in sinus rhythm
• Abstracts: Improved detection of coronary artery disease by exercise electrocardiography with the use of right precordial leads
• Abstracts: Managing patients undergoing radiation. Optical device helps detect oral cancer. Current management of oral cancer: a multidisciplinary approach

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.