Differential impact on thymidine analogue mutations of emtricitabine and lamivudine susceptibility

Article Abstract:

The phenotypic impact of commonly observed nucleoside reverse transcriptase inhibitors (NRTIs) resistance-associated mutations in the absence of M1841 or V was examined using patient samples with paired susceptibility results of lamivudine (3TC) and emtricitabine (FTC) to determine if difference exists. Results reveal that 3TC and FTC might provide differential efficacy in some patient with prior NRT1 experience or in patients infected with virus harboring thymidine analogue mutations (TAMs) in the absence of M184V or I.

Lamivudine, Thymidine

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Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice

Article Abstract:

The study aims to identify and compare the range, severity, and frequency of hypophosphatemia (HP) in tenofovir disproxil fumarate (TDF) recipients versus non-TDF recipients and assesses the reproducibility of HP in TDF recipients in the absence of intervention. It also identified any association between renal dysfunction and HP and evaluated any other associations with HP, including host factors and HIV disease or treatment factors.

Drug therapy, HIV (Viruses), HIV, Hypophosphatemia, Tenofovir

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