Differing mechanisms of inhibition of calcium increases in human uterine myocytes by indomethacin and nimesulide

Article Abstract:

Indomethacin causes an increase in calcium inside muscle cells that occurs even in the presence of prostaglandin. This shows that indomethacin acts in ways other than by inhibiting prostaglandin synthesis. Indomethacin is one of the drugs that is used to stop premature labor.

Prevention, Premature labor, Muscle cells, Indomethacin

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The mechanism of propagation of intracellular calcium waves in cultured human uterine myocytes

Article Abstract:

Calcium in uterine tissue can be released from sarcoplasmic reticulum via the inositol 1,4,5-triphosphate receptors or the ryanodine receptors or both. Intercellular waves of calcium are involved in uterine contraction.

Cell receptors, Uterus, Uterine contractions

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Oxytocin-induced desensitization of the oxytocin receptor

Article Abstract:

Research has been conducted on oxytocin-induced desensitization of the oxytocin receptor. The authors characterized this desensitization in cultured human myocytes.

United States, Research and Development in the Physical, Engineering, and Life Sciences, Science & research, Research and Testing Services, Gynecological R&D, Analysis, Oxytocin, Obstetrics, Gynecological research

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