Dilated cardiomyopathy: learning to live with yourself

Article Abstract:

Dilated cardiomyopathy caused by adenovirus or specific strain of coxsackie virus is demonstrated with the help of animal model. The acute immunological reaction to the viral infection, in a susceptible genetic background, leads to the development of an autoimmune reaction targeted against cardiac antigens, which is supported by presenting compelling data.

Coxsackieviruses

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Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

Article Abstract:

30-kDa protein is purified from heart extract and is identified as cardiac troponin I (cTnl) encoded by a gene in which mutations can cause familial hypertrophic cardiomyopathy (HCM). Experimental finding suggests that monoclonal antibodies to cTnI induce heart dysfunction and dilatation by chronic stimulation of Ca(super +2) influx in cardiomyocytes.

Influence, Mutation (Biology), Mutation, Troponin

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Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

Article Abstract:

This article explains that the infection of gastric epithelial cells plays a major role in causing gastric cancer. It is found that aberrant activation-induced cytidine deaminase caused by the helicobacter pylori infection may be the cause for gastric carcinogenesis.

United States, Care and treatment, Risk factors, Helicobacter pylori, Stomach cancer, Pyrimidine nucleotides

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