Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice

Article Abstract:

The mechanism of enhanced insulin sensitivity and adipose mitochondrial biogenesis in AdipoPten-KO mice is examined by analyzing various molecules involved in insulin mediated signaling and cell cycling in adipose tissue by western blotting. The findings suggest that suppression of mRNA expression or activity of adipose Pten could be therapeutically effective for type 2 diabetes and obesity, through the enhancement of insulin sensitivity and energy expenditure.

United States, Mice as laboratory animals, House mouse, Drug testing, Insulin

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Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing

Article Abstract:

Conventional gene therapy of hemophilia A relies on the transfer of factor VIII (FVIII; encoded by the F8 gene) cDNA. A pre-trans-splicing molecule corrected endogenous FVIII mRNA in F8 knockout mice with the hemophilia A phenotype, producing sufficient functional FVIII to correct the hemophilia A phenotype.

Gene therapy

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Catalytic activity of antibodies against factor VIII in patients with hemophilia A

Article Abstract:

Researchers report that some autoantibodies against factor VIII are catalytic in nature. Patients with hemophilia take factor VIII, but the body often produces antibodies against it. The alloantibodies in this report are site-specific proteases.

Catalytic antibodies

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