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Disparities in clinical laboratory performance for blood lead analysis

Article Abstract:

Some medical laboratories may have a high rate of misclassifying measurements of lead in blood samples, which may result in lack of treatment for children with high blood lead levels. Researchers sent blood lead samples to 18 laboratories for analysis. Differences in laboratory performance were attributed to systematic, random, and human error. One large state laboratory reported blood samples with a high actual blood lead concentration as being within the acceptable range. This laboratory, handling a large volume of blood samples, may be causing many children with treatable lead exposure to go untreated. Physicians who send blood samples to medical laboratories for testing should be able to obtain data on the accuracy of the testing procedure. The atomic absorption spectroscopy method appears to be superior to anodic stripping voltammetry.

Author: Sargent, James D., Johnson, Lloyd, Roda, Sandy
Publisher: American Medical Association
Publication Name: Archives of Pediatrics & Adolescent Medicine
Subject: Health
ISSN: 1072-4710
Year: 1996
Diagnosis, Lead poisoning

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Accuracy and reproducibility of blood lead testing in commercial laboratories

Article Abstract:

Most clinical laboratories seem capable of accurately measuring lead levels in blood samples. Researchers sent 20 blood samples to eight clinical laboratories to be tested for lead. Five of the laboratories were commercial and one was the Center for Disease Control and Prevention's reference laboratory. The samples were from seven humans and also included three blood samples from cows with known levels of lead. All the laboratories reported similar blood lead levels. The human samples were drawn two weeks apart and the labs also reported consistent lead levels in these samples.

Author: Gochfeld, Michael, Jones, Robert, Rhoads, George G., Cody, Ronald P., Buckler, Gail, Jobanputra, Nishith K., Matte, Thomas M., Rich, David Q.
Publisher: American Medical Association
Publication Name: Archives of Pediatrics & Adolescent Medicine
Subject: Health
ISSN: 1072-4710
Year: 1998
Evaluation, Medical laboratories, Biomedical laboratories

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Predictors of smoking cessation in adolescents

Article Abstract:

Adolescents who only smoke occasionally may be more likely to quit smoking than those who use cigarettes daily. Researchers surveyed 276 high school-aged smokers, then resurveyed them annually for several years. At the first survey, 26% of smokers reported that they wanted to quit. On subsequent surveys, 46% of occasional smokers, 12% of daily smokers of nine or fewer cigarettes, and 7% of daily smokers of 10 or more cigarettes had successfully quit smoking. Daily smoking, more likely to lead to nicotine addiction, may make smoking cessation more difficult.

Author: Stevens, Marguerite, Mott, Leila A., Sargent, James D.
Publisher: American Medical Association
Publication Name: Archives of Pediatrics & Adolescent Medicine
Subject: Health
ISSN: 1072-4710
Year: 1998
Demographic aspects, Smoking cessation programs, Smoking cessation, Smoking and youth, Youth smoking

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Subjects list: Measurement, Blood, Lead in the body, Blood chemical analysis
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